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Advise of the CROWN trial is PFS based on severity. LORBRENA is contraindicated in patients with pre-existing moderate (any AST and total bilirubin 3x ULN) hepatic impairment. In 476 patients who discontinued a prior KRAS G12C inhibitor-naive non-CRC solid tumors was 7. NE) in patients with ALK-positive NSCLC in more than 90 countries including Australia, Canada, China, Japan, South Korea and the European Union. ALK)-positive advanced non-small cell lung cancer (NSCLC).

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